ParkinsonCanadaV1, Main, Exploration, bibRecord, 002106

Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease

Identifieur interne : 002106 ( Main/Exploration ); précédent : 002105; suivant : 002107

Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease

Auteurs : Abdoul Kane [Canada] ; William D. Hutchison [États-Unis, Canada] ; Mojgan Hodaie [États-Unis, Canada] ; Andres M. Lozano [États-Unis, Canada] ; Jonathan O. Dostrovsky [États-Unis, Canada]

Source :

Neuroreport : (Oxford) [ 0959-4965 ] ; 2009.

RBID : Pascal:10-0009361

Descripteurs français

Pascal (Inist)
- Dopamine, Haute fréquence, Thalamus, Noyau sousthalamique, Potentiel champ, Maladie de Parkinson, Homme, Stimulation cérébrale profonde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Deep brain stimulation, Dopamine, Field potential, High frequency, Human, Parkinson disease, Subthalamic nucleus, Thalamus.

Abstract

In recent years there has been great interest in oscillatory activity in the brain and in the role of pathological oscillations in the basal ganglia in mediating some of the symptoms of Parkinson's disease (PD). In this study, thalamic and subthalamic nucleus local field potentials were intraoperatively recorded from pairs of closely separated microelectrodes in six PD patients ON and OFF dopaminergic medication. Using correlation and coherence analyses, we found high-frequency oscillatory activity in the 110-170 Hz band in thalamus in patients OFF dopamine. These oscillations were significantly reduced after administration of dopamine-replacement therapy. In contrast, activity in the lower frequencies (the θ and β ranges) was increased. However, in subthalamic nucleus, we observed an increase in high-frequency oscillatory activity (150-200 Hz), and a reduction of the activity in the low-frequency range after levodopa administration. These findings confirm and extend earlier findings suggesting that in PD there are marked changes in basal ganglia oscillatory activity and that these can be reversed after dopaminergic therapy.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">In recent years there has been great interest in oscillatory activity in the brain and in the role of pathological oscillations in the basal ganglia in mediating some of the symptoms of Parkinson's disease (PD). In this study, thalamic and subthalamic nucleus local field potentials were intraoperatively recorded from pairs of closely separated microelectrodes in six PD patients ON and OFF dopaminergic medication. Using correlation and coherence analyses, we found high-frequency oscillatory activity in the 110-170 Hz band in thalamus in patients OFF dopamine. These oscillations were significantly reduced after administration of dopamine-replacement therapy. In contrast, activity in the lower frequencies (the θ and β ranges) was increased. However, in subthalamic nucleus, we observed an increase in high-frequency oscillatory activity (150-200 Hz), and a reduction of the activity in the low-frequency range after levodopa administration. These findings confirm and extend earlier findings suggesting that in PD there are marked changes in basal ganglia oscillatory activity and that these can be reversed after dopaminergic therapy.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease

Dopamine-dependent high-frequency oscillatory activity in thalamus and subthalamic nucleus of patients with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri